BLACK BUG ROOM

“And so then, The Student would leave the room, have a real let-down and then begin to exhibit acute neurotic symptoms, as well as a complete inability to do Intellectual Work.

In effect, if you begin pulling-up in Analysis what had happened to these people, on an unconscious level, the effect was as-though a large, slightly-more-than-man-sized black beetle had performed sodomic rape on them.”

"It doesn't kill you. 

What it does is make you feel like you're in a noisy little dark room... naked and ashamed... and there are things in the dark that need to hurt you because you're bad... little pinching things that go in your ears and crawl on the inside of your skull. 

And you know that if the noise and the crawling would stop... that you could remember how to get out... 

But you never, ever will."

— Glory describing the effects of her brain suck to Tara, 

Buffy the Vampire Slayer

Described in the Illuminatus! novels as Chapel Perilous. All the principal characters have to "walk that lonesome valley" to the Chapel and confront their deepest and most primal fears before moving on. Some require repeat visits.

Room 101 in George Orwell's Nineteen Eighty-Four is the Black Bug room made manifest. With, for Winston Smith, extra added rats.